Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis
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چکیده
منابع مشابه
Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis
The branching behaviors of both dendrites and axons are part of a neuronal maturation process initiated by the generation of small and transient membrane protrusions. These are highly dynamic, actin-enriched structures, collectively called filopodia, which can mature in neurons to form stable branches. Consequently, the generation of filopodia protrusions is crucial during the formation of neur...
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During brain development, proper neuronal migration and morphogenesis is critical for the establishment of functional neural circuits. Here we report that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains in vivo and in vitro. P...
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In large cells like neurons, how is microtubule polymerization initiated at large distances from the cell body and the main microtubule-organizing center? In this issue of Neuron, Ori-McKenney et al. (2012) demonstrate that Golgi outposts mediate acentrosomal microtubule nucleation and reveal it is crucial for dendrite morphogenesis.
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2015
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1002241